While evidence for the role of gap functions, particularly during development, has been mounting, it has remained largely correlative, linking structure with presumed functions. With the recent advent of functional antibodies raised to the junctional protein, however, it has become possible to study the role of gap junctions more directly. There is now considerable evidence indicating that they play a vital role in tissue pattern formation and differentiation by allowing direct cell‐to‐cell transfer of developmental signals or morphogens.

While green innovation has a positive impact on firms’ performance, some established firms that initiate green innovation activities could suffer from insufficient new green knowledge and skills. Since adopting a sustainability orientation helps firms commit to the creation of superior sustainable practices, and efficiently invest resources necessary to develop appropriate new green products, leading to superior green innovation performance, sustainability orientation offers an alternative approach for diversifying green entrants to achieve green innovation success. (...) Building on resource-based, knowledge-based, and capabilities theories, this study aims to identify key factors that enable sustainability orientation of diversifying green entrants and enhance its effect on green innovation performance. As sustainability issues frequently occur upstream at the supplier level, and since supplier involvement effectively determines new product success, this study theorizes that diversifying green entrants that adopt sustainability orientation require two types of green supplier involvement to enhance the effect of sustainability orientation on green innovation performance. Green knowledge-processing capability and green R&D capability complement green supplier involvement as a knowledge source and green supplier involvement as a co-creator, respectively, to further enhance the amount of green innovation performance. Based on a longitudinal dataset of 336 diversifying green entrants, the results support all our hypotheses. Interestingly, an additional analysis suggests that when diversifying green entrants implement green supplier involvement as a co-creator, they achieve greater green innovation performance than those who implement green supplier involvement as a knowledge source. These findings provide important theoretical implications and practical guidance for established firms to pursue green innovation. (shrink)

Along with utilitarianism, British idealism was the most important philosophical and practical movement in Britain and its Empire during the late-nineteenth and early-twentieth centuries. Even though the British idealists have regained some of their standing in the history of philosophy, their own historical theories still fail to receive the deserved scholarly attention. This article helps to fill that major gap in the literature. Understanding historiography as concerning the appropriate modes of enquiring into the recorded past, this article analyses the key (...) historiographical commitments that underpin the writings of the early T.H. Green (section two), Edward Caird (section three), and F.H. Bradley (sections four and five). Section six explores the influence of Bradley's historiography. These approaches are linked by the belief that all thought can be properly understood only by critical historians who possess the appropriate tools with which to distinguish permanently valid truths from the transient imperfections with which those truths are mixed. A crucial division between them is the invocation of a neo-Hegelian Geist by the early Green and Caird, and Bradley's reliance on a progressive human nature. Moreover, the article establishes that R.G. Collingwood's highly influential theories of “absolute presuppositions” and “re-enactment” were taken largely from Bradley's historiography. (shrink)

ABSTRACTThis article surveys and contextualizes the British idealists’ philosophical writings on language, aesthetics and emotions, starting with T. H. Green and concluding with Michael Oakeshott. It highlights ways in which their philosophical insights have been wrongly overlooked by later writers. It explores R. L. Nettleship’s posthumous publications in this field and notes that they exerted significant influences on British idealists and closely related figures, such as Bernard Bosanquet and R. G. Collingwood. The writing of other figures are also explored, (...) not least F. H. Bradley and J. A. Smith. The article concludes by introducing in turn the remaining articles that are found in this special issue. (shrink)

Logical consequence is the relation that obtains between premises and conclusion(s) in a valid argument. Orthodoxy has it that valid arguments are necessarily truth-preserving, but this platitude only raises a number of further questions, such as: how does the truth of premises guarantee the truth of a conclusion, and what constraints does validity impose on rational belief? This volume presents thirteen essays by some of the most important scholars in the field of philosophical logic. The essays offer ground-breaking new insights (...) into the nature of logical consequence; the relation between logic and inference; how the semantics and pragmatics of natural language bear on logic; the relativity of logic; and the structural properties of the consequence relation. (shrink)

Agroecology has been proposed as a key building block for food sovereignty. This article examines the meaning, practices and potentials of ‘transformative agroecology learning’ as a collective strategy for food system transformation. Our study is based on our qualitative and action research with the European Coordination of Via Campesina to develop the European Agroecology Knowledge Exchange Network. This network is linked to the global network of La Via Campesina and builds on the strong experiences and traditions of popular education in (...) Latin American peasant movements. Rather than focusing on agroecology education as a process of individual learning, we analyse how a transformative agroecology education can be strengthened as a critical repertoire of action used by social movements to advance food sovereignty. Our analysis contributes a new theory of transformative agroecology learning based on four key characteristics or qualities: horizontalism; diálogo de saberes ; combining practical and political knowledge; and building social movement networks. While these different elements of transformative agroecology learning were present across EAKEN, they were unevenly developed and, in many cases, not systematized. The framework can help to strategically and reflexively systematize and strengthen a transformative agroecology learning approach as a key building block for food sovereignty. (shrink)

Recent work in philosophical logic has taken interesting and unexpected turns. It has seen not only a proliferation of logical systems, but new applications of a wide range of different formal theories to philosophical questions. As a result, philosophers have been forced to revisit the nature and foundation of core logical concepts, chief amongst which is the concept of logical consequence. This essay sets the contributions of the volume in context and identifies how they advance important debates within the philosophy (...) of logic. (shrink)

According to Jago (2014a), logical omniscience is really part of a deeper paradox. Jago develops an epistemic logic with principles of indeterminate closure to solve this paradox, but his official semantics is difficult to navigate, it is motivated in part by substantive metaphysics, and the logic is not axiomatized. In this paper, I simplify this epistemic logic by adapting the hyperintensional semantic framework of Sedlár (2021). My first goal is metaphysical neutrality. The solution to the epistemic paradox should not require (...) appeal to a metaphysics of truth-makers, situations, or impossible worlds, by contrast with Jago’s official semantics. My second goal is to elaborate on the proof theory. I show how to axiomatize a family of logics with principles of indeterminate epistemic closure. (shrink)

This paper is about the underlying logical principles of scientific theories. In particular, it concerns ex contradictione quodlibet (ECQ) the principle that anything follows from a contradiction. ECQ is valid according to classical logic, but invalid according to paraconsistent logics. Some advocates of paraconsistency claim that there are ‘real’ inconsistent theories that do not erupt with completely indiscriminate, absurd commitments. They take this as evidence in favor of paraconsistency. Michael (2016) calls this the non-triviality strategy (NTS). He argues that this (...) strategy fails in its purpose. I will show that Michael's criticism significantly over-reaches. The fundamental problem is that he places more of a burden on the advocate of paraconsistency than on the advocate of classical logic. The weaknesses in Michael's argument are symptomatic of this preferential treatment of one viewpoint in the debate over another. He does, however, make important observations that allow us to clarify some of the complexities involved in giving a logical reconstruction of a theory. I will argue that there are abductive arguments deserving of further consideration for the claim that paraconsistent logic offers the best explanation of the practice of inconsistent science. In this sense, the debate is still very much open. (shrink)

According to the logical pluralism of Beall and Restall, there are several distinct relations of logical consequence. Some critics argue that logical pluralism suffers from what I call the collapse problem: that despite its intention to articulate a radically pluralistic doctrine about logic, the view unintentionally collapses into logical monism. In this paper, I propose a contextualist resolution of the collapse problem. This clarifies the mechanism responsible for a plurality of logics and handles the motivating data better than the original (...) view. It is a major improvement that should be embraced by all logical pluralists. (shrink)

In a recent series of articles, Beall has developed the view that FDE is the formal system most deserving of the honorific “Logic”. The Simple Argument for this view is a cost-benefit analysis: the view that FDE is Logic has no drawbacks and it has some benefits when compared with any of its rivals. In this paper, I argue that both premises of the Simple Argument are mistaken. I use this as an opportunity to further reflect on how such arguments (...) can be bolstered to provide more substantial and productive support for revisionary theses about Logic. (shrink)

This paper scrutinizes the debate over logical pluralism. I hope to make this debate more tractable by addressing the question of motivating data: what would count as strong evidence in favor of logical pluralism? Any research program should be able to answer this question, but when faced with this task, many logical pluralists fall back on brute intuitions. This sets logical pluralism on a weak foundation and makes it seem as if nothing pressing is at stake in the debate. The (...) present paper aims to improve this situation by looking at a promising case study and drawing general lessons about the kind of evidence that would support logical pluralism. I argue that the best motivation for logical pluralism will ultimately be rooted in certain kinds of performative data. (shrink)

This note motivates a logic for a theory that can express its own notion of logical consequence—a ‘syntactically closed’ theory of naive validity. The main issue for such a logic is Curry’s paradox, which is averted by the failure of contraction. The logic features two related, but different, implication connectives. A Hilbert system is proposed that is complete and non-trivial.

The advocate of modal logic or relevant logic has traditionally argued that her preferred system offers the best regimentation of the theory of entailment. Essential to the projects of modal and relevant logic is the importation of non-truth-functional expressive resources into the object language on which the logic is defined. The most elegant technique for giving the semantics of such languages is that of frame semantics, a variation on which features the device of partitioned frames that divide 'points of evaluation' (...) into two types: normal points and abnormal points. This essay attempts to provide satisfying philosophical interpretations of the partitioned frame semantics for some weak modal logics and relevant logics. According to the current best interpretation, partitioned frame semantics are a kind of possible worlds semantics that appeal to 'logically impossible worlds' where the laws of logic may fail to hold. This is undermined by the fact that all of the target logics fail to satisfy criteria of expressibility needed to support the thesis that laws of logic fail to hold at abnormal points. This suggests that we should not look for a monistic interpretive paradigm for partitioned frame semantics. (shrink)

I argue that, contrary to how he is often read, Spinoza did not believe that the mind and the body were numerically identical. This means that we must find some alternative reading for his claims that they are 'one and the same thing'.

During development of the Xenopus embryo, the formation of the nervous system depends on an inductive interaction between mesoderm and ectoderm. The result is a neural tube that is regionally differentiated along the anterior–posterior axis from forebrain to spinal cord (Fig. 1). The discovery of genes whose transcripts can be used as molecular markers for different regions of the nervous system has permitted reassessment of the existing theories of neural tissue formation. Although the neural inducing molecules remain elusive, the mechanism (...) by which cells interact to form a regionally differentiated nervous system is becoming clearer. (shrink)

Local sustainable food systems have captured the popular imagination as a progressive, if not radical, pillar of a sustainable food future. Yet these grassroots innovations are embedded in a dominant food regime that reflects productivist, industrial, and neoliberal policies and institutions. Understanding the relationship between these emerging grassroots efforts and the dominant food regime is of central importance in any transition to a more sustainable food system. In this study, we examine the encounters of direct farm marketers with food safety (...) regulations and other government policies and the role of this interface in shaping the potential of local food in a wider transition to sustainable agri-food systems. This mixed methods research involved interview and survey data with farmers and ranchers in both the USA and Canada and an in-depth case study in the province of Manitoba. We identified four distinct types of interactions between government and farmers: containing, coopting, contesting, and collaborating. The inconsistent enforcement of food safety regulations is found to contain progressive efforts to change food systems. While government support programs for local food were helpful in some regards, they were often considered to be inadequate or inappropriate and thus served to coopt discourse and practice by primarily supporting initiatives that conform to more mainstream approaches. Farmers and other grassroots actors contested these food safety regulations and inadequate government support programs through both individual and collective action. Finally, farmers found ways to collaborate with governments to work towards mutually defined solutions. While containing and coopting reflect technologies of governmentality that reinforce the status quo, both collaborating and contesting reflect opportunities to affect or even transform the dominant regime by engaging in alternative economic activities as part of the ‘politics of possibility’. Developing a better understanding of the nature of these interactions will help grassroots movements to create effective strategies for achieving more sustainable and just food systems. (shrink)

The semantic tradition in logic descends from Tarski's seminal work on truth and logical consequence. In the introduction to this volume, Sagi and Woods remind us that this tradition prominently uses model theory to study languages and their interpretations. Tarski's model-theoretic definition of logical consequence is the prime example of this approach, seeking as it does to reduce logical properties to a class of operations on classical, iterative (ZF) sets. Sagi and Woods explain with admirable clarity the origins, implications, and (...) philosophical questions surrounding this project. The contributions to the volume go on to address whether this approach successfully elucidates logicality and how it intersects with the foundations of mathematics and natural language semantics. (shrink)

Transposable elements (TEs) are powerful facilitators of genome evolution, and hence of phenotypic diversity as they can cause genetic changes of great magnitude and variety. TEs are ubiquitous and extremely ancient, and although harmful to some individuals, they can be very beneficial to lineages. TEs can build, sculpt, and reformat genomes by both active and passive means. Lineages with active TEs or with abundant homogeneous inactive populations of TEs that can act passively by causing ectopic recombination are potentially fecund, adaptable, (...) and taxonate readily. Conversely, taxa deficient in TEs or possessing heterogeneous populations of inactive TEs may be well adapted in their niche, but tend to prolonged stasis and may risk extinction by lacking the capacity to adapt to change, or diversify. Because of recurring intermittent waves of TE infestation, available data indicate a compatibility with punctuated equilibrium, in keeping with widely accepted interpretations of evidence from the fossil record. We propose a general and holistic synthesis on how the presence of TEs within genomes makes them flexible and dynamic, so that genomes themselves are powerful facilitators of their own evolution. (shrink)

Local sustainable food systems have captured the popular imagination as a progressive, if not radical, pillar of a sustainable food future. Yet these grassroots innovations are embedded in a dominant food regime that reflects productivist, industrial, and neoliberal policies and institutions. Understanding the relationship between these emerging grassroots efforts and the dominant food regime is of central importance in any transition to a more sustainable food system. In this study, we examine the encounters of direct farm marketers with food safety (...) regulations and other government policies and the role of this interface in shaping the potential of local food in a wider transition to sustainable agri-food systems. This mixed methods research involved interview and survey data with farmers and ranchers in both the USA and Canada and an in-depth case study in the province of Manitoba. We identified four distinct types of interactions between government and farmers: containing, coopting, contesting, and collaborating. The inconsistent enforcement of food safety regulations is found to contain progressive efforts to change food systems. While government support programs for local food were helpful in some regards, they were often considered to be inadequate or inappropriate and thus served to coopt discourse and practice by primarily supporting initiatives that conform to more mainstream approaches. Farmers and other grassroots actors contested these food safety regulations and inadequate government support programs through both individual and collective action. Finally, farmers found ways to collaborate with governments to work towards mutually defined solutions. While containing and coopting reflect technologies of governmentality that reinforce the status quo, both collaborating and contesting reflect opportunities to affect or even transform the dominant regime by engaging in alternative economic activities as part of the ‘politics of possibility’. Developing a better understanding of the nature of these interactions will help grassroots movements to create effective strategies for achieving more sustainable and just food systems. (shrink)

A common account sees the human genome sequencing project of the 1990s as a “natural outgrowth” of the deciphering of the double helical structure of DNA in the 1950s. The essay aims to complicate this neat narrative by putting the spotlight on the field of human chromosome research that flourished at the same time as molecular biology. It suggests that we need to consider both endeavors – the human cytogeneticists who collected samples and looked down the microscope and the molecular (...) biologists who probed the molecular mechanisms of gene function – to understand the rise of the human genome sequencing project and the current genomic practices. In particular, it proposes that what has often been described as the “molecularization” of cytogenetics could equally well be viewed as the turn of molecular biologists to human and medical genetics – a field long occupied by cytogeneticists. These considerations also have implications for the archives that are constructed for future historians and policy makers. (shrink)

The patient wished to receive an experimental drug that she was instrumental in developing. After her diagnosis, she had investigated treatments that might help her condition and discovered that a specific compound could be beneficial. To further the development of this potential drug, she obtained preclinical data, founded a company, and sought investment from venture capitalists. The company was about to begin phase I testing, but the clinical trial had not yet opened. In addition, she would not have been a (...) candidate for the study, as it excluded patients with advanced disease. To be able to administer this drug to her, the patient's team of oncologists was in the process of drafting an individual patient investigational new drug application, including the protocol for the drug's delivery, to the Food and Drug Administration. The company developing the drug had preliminarily agreed to provide it. This protocol was also under review by the institutional review board of the university, and the ethics committee was consulted to determine whether she should receive the drug. (shrink)

This case is another in a series intended to highlight the new questions emerging from advances in mapping the human genome and the application of genetic findings to clinical practice. The National Human Genome Research Institute, a component of the National Institutes of Health, by law is directed to designate a portion of its annual budget to furthering understanding of the ethical, legal, and social questions emerging from research on the human genome. As part of the effort, the Institute supports (...) research by scientists and scholars around the nation with the aim of clarifying and resolving the tough ethical and research choices facing this endeavor. But recently it has launched an intramural program, which is expected to take a catalytic role in grappling with the array of issues the researchers face in carrying out investigations in human genetics. (shrink)

PurposeAdvance directives have been criticized for failing to help physicians make decisions consistent with patients’ wishes. This pilot study sought to determine if an interactive, computer-based decision aid that generates an advance directive can help physicians accurately translate patients’ wishes into treatment decisions.MethodsWe recruited 19 patient-participants who had each previously created an advance directive using a computer-based decision aid, and 14 physicians who had no prior knowledge of the patient-participants. For each advance directive, three physicians were randomly assigned to review (...) the advance directive and make five to six treatment decisions for each of six (potentially) end-of-life clinical scenarios.From the three individual physicians’ responses, a “consensus physician response” was generated for each treatment decision (total decisions = 32). This consensus response was shared with the patient whose advance directive had been reviewed, and she/he was then asked to indicate how well the physician translated his/her wishes into clinical decisions.ResultsPatient-participants agreed with the consensus physician responses 84 percent (508/608) of the time, including 82 percent agreement on whether to provide mechanical ventilation, and 75 percent on decisions about cardiopulmonary resuscitation (CPR).Across the six vignettes, patient-participants’ rating of how well physicians translated their advance directive into medical decisions was 8.4 (range = 6.5-10, where 1 = extremely poorly, and 10 = extremely well). Physicians’ overall rating of their confidence at accurately translating patients’ wishes into clinical decisions was 7.8 (range = 6.1-9.3, 1 = not at all confident, 10 = extremely confident).ConclusionFor simulated cases, a computer-based decision aid for advance care planning can help physicians more confidently make end-of-life decisions that patients will endorse. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:LettersMaxwell J. Mehlman, Susan R. Massey, Ronald M. Green, and Fred RosnerPhysicians and the Allocation of Scarce ResourcesMadam: We read with interest Dr. Pellegrino's commentary on our article in the December 1994 issue of the Kennedy Institute of Ethics Journal, and commend him for pointing out so well the different ways that law and ethics approach the issue of physician allocation of scarce resources.We wish to make one (...) clarification. Dr. Pellegrino states that we propose that fiduciary duties be abolished. Quite the contrary, our position is that fiduciary obligations are essential to the maintenance of trust—which we believe to be an efficient as well as an ethical element of the patient-provider relationship. If fiduciary duties are undercut, as we pointed out they are by the Oregon Medicaid legislation, then some other method of promoting trust must be established, and, as we point out in the article, it is difficult to identify what that method could be.Maxwell J. MehlmanandSusan R. MasseyThe Law Medicine CenterArter & HaddenCase Western Reserve UniversityCleveland, OHSchool of LawCleveland, OHReport of the Human Embryo Research PanelMadam: In the December 1994 issue of the Kennedy Institute of Ethics Journal, I reported on the controversy surrounding the work of the NIH Human Embryo Research Panel and the conclusions reached in its report, which was formally presented to NIH Director Harold Varmus on September 27, 1994. At that time, the report was to be reviewed by the Advisory Committee to the Director (ACD) until its next meeting in early December. I am writing to update your readers on the fate of the Panel's report.On the morning of December 2, 1994, following a previous afternoon of animated discussion, the ACD unanimously accepted the Report of the Human Embryo Research Panel. Panel members and members of the NIH staff who were present and had worked for nearly a year on the Report were gratified by this vote of confidence and by the strong support of NIH Director Harold Varmus.We had little time to enjoy this success. Within a matter of hours, the White House issued a press release in which President Clinton thanked the committee for its work and then, in a remark overruling one of the key recommendations in our report, stated: "I do not believe that federal funds should be used to support the creation of human embryos for research purposes, and I have directed that NIH not allocate any resources for such research." [End Page 83]As a Panel member and active participant in that day's events, my initial response was one of shock. I was particularly distressed that the President and his advisors chose a moment so late in the process to make their views known. Why had we worked for months, I asked, without a word of concern from the White House? Although Panel members were guided primarily by our perceptions of the ethical and scientific issues involved, some were close to the political realities of Washington and would have introduced these concerns into the Panel's deliberations.Within a matter of days, my own sense of outrage had diminished. First of all, it was clear that whatever the personal sources of the President's objections to the Panel's recommendations, this high level political intervention was inevitable. Less than a month before, on November 8, with the election of a majority House and Senate, the political environment for embryo research had changed dramatically. The previous June, 32 congressmen, most of them members of a minority Republican party, had signed a letter protesting the Panel's work. Now, one of the signers of that letter, Newt Gingrich, was destined to be Speaker of the House.Second, it became clear that the damage was not total. The President has forbidden NIH to support work involving the deliberate creation of embryos for research. Without exception, members of the Panel had come to the conclusion that some development of "research embryos" must be permitted to reduce the risks of new assisted reproductive technologies, to enhance scientific knowledge, and to develop new therapies for a range of serious diseases. All these... (shrink)

The Quine/Putnam indispensability argument is regarded by many as the chief argument for the existence of platonic objects. We argue that this argument cannot establish what its proponents intend. The form of our argument is simple. Suppose indispensability to science is the only good reason for believing in the existence of platonic objects. Either the dispensability of mathematical objects to science can be demonstrated and, hence, there is no good reason for believing in the existence of platonic objects, or their (...) dispensability cannot be demonstrated and, hence, there is no good reason for believing in the existence of mathematical objects which are genuinely platonic. Therefore, indispensability, whether true or false, does not support platonism. Mathematical platonists claim that at least some of the objects which are the subject matter of pure mathematics (e.g. numbers, sets, groups) actually exist. Furthermore, they claim that these objects differ radically from the concrete objects (trees, cats, stars, molecules) which inhabit the material world. We take the standard platonistic position to include the claim that platonic objects lack spatio-temporal location and causal powers. Many (perhaps most) mathematical platonists subscribe to this view.1 But some who call themselves (or might be called) mathematical platonists.. (shrink)